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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight loss in addition to a reduced-calorie diet and physical exercise.

Using two separate drugs to shed weight can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you should err assisting caution and allow the FDA do its job and demand some research be done so the public recognizes the side effects and risks of the medications before we drive them. Keep in mind that drug companies come in business to generate money and that they would say almost anything to keep people on their medications.

Researchers found out that participants taking this drug for any year, dropped excess weight within one month and have kept the extra weight off throughout the 56 weeks of the study. Contrave is a combination with the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which can be made up of multiple active ingredient, which can make them more efficient and safer.

Combo-pilling could be the newest fad or better yet the newest in the future under scrutiny and thus it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular may be the fact that by right now there aren't long term prescription slimming capsules that have been licensed by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug also can raise blood pressure and heart rate, and shouldn't be used in individuals with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure level and heartrate and must 't be used in patients with uncontrolled high blood pressure, in addition to by you aren't heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients to the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.

"There were no signs of depression or suicidal thoughts in trial participants," said Fujioka.

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